Phosphate Monoester Hydrolysis in Cyclohexane
نویسندگان
چکیده
منابع مشابه
The Competing Mechanisms of Phosphate Monoester Dianion Hydrolysis
Despite the numerous experimental and theoretical studies on phosphate monoester hydrolysis, significant questions remain concerning the mechanistic details of these biologically critical reactions. In the present work we construct a linear free energy relationship for phosphate monoester hydrolysis to explore the effect of modulating leaving group pKa on the competition between solvent- and su...
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Understanding phosphoryl and sulfuryl transfer is central to many biochemical processes. However, despite decades of experimental and computational studies, a consensus concerning the precise mechanistic details of these reactions has yet to be reached. In this work we perform a detailed comparative theoretical study of the hydrolysis of p-nitrophenyl phosphate, methyl phosphate and p-nitrophen...
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Coenzyme A (CoA) has been found to contain three phosphate groupings per molecule (4, 5). One of these has been found in the monoester form, since 1 mole of phosphate is liberated from 1 mole of CoA by the prostatic monoesterase (4, 5). This monoester phosphate has been ascertained to be on the adenylic acid moiety of the coenzyme (6). Through the use of a specific 3’-nucleotidase (I), prelimin...
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The aim of this work was to construct chemical models for selective hydrolysis of phosphate monoesters in order to elucidate the role of metal ions in the hydrolytic mechanisms and to develop artificial enzymes for practical applications. A dinuclear copper(II) complex of a cyclohexane-based polyamino polyalcohol provided a selective and by far the highest rate acceleration among the transition...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2009
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja907967y